Ithiphu ye-pipette ethobekile incane, ayibizi, futhi ibalulekile kwisayensi. Inika amandla ucwaningo emithini emisha, ukuxilongwa kwe-Covid-19 kanye nakho konke ukuhlolwa kwegazi.
Kepha manje, uchungechunge lokuphazamiseka okungazelelwe ochungechungeni lokuhlinzekwa kwetiphu ye-pipette ngenxa yokunqamuka kukagesi, imililo kanye nezidingo ezihlobene nobhubhane kudale ukushoda komhlaba wonke okusongela cishe wonke amagumbi omphakathi wesayensi.
Ukushoda kwamathiphu e-pipette kubeke engcupheni uhlelo lukazwelonke lokuhlola izingane ezisanda kuzalwa izifo ezingase zibulale, njengokungakwazi ukugaya ushukela obisini lwebele.Kusongela ukuhlolwa kwe-stem cell genetics enyuvesi.Kuphinde kuphoqe izinkampani ze-biotech ezisebenzela ukwakha imithi emisha okufanele icatshangelwe. ukubeka kuqala izivivinyo ezithile kunezinye.
Njengamanje, akukho sibonakaliso sokuthi ukushoda kuzophela noma nini maduze - uma izinto ziba zimbi kakhulu, ososayensi kungase kudingeke baqale ukubambezela ukuhlola noma balahle omunye wemisebenzi yabo.
"Umbono wokukwazi ukwenza isayensi ngaphandle kwabo uyahlekisa," kusho uGabrielle Bostwick, umphathi zelabhorethri kwa-Octant Bio, isiqalo sebhayoloji yokwenziwa eseCalifornia.
Kubo bonke ososayensi abaphatheke kabi ngokushoda kwezingane, abacwaningi abajutshwe ukuthi bahlole izingane yibona abahleleke kakhulu nabakhuluma ngokungagwegwesi.
Amalebhu ezempilo yomphakathi ahlola izingane ngenqwaba yezinkinga zofuzo phakathi namahora okubeletha.Ezinye, njenge-phenylketonuria kanye nokuntuleka kwe-MCAD, zidinga ukuthi odokotela benze izinguquko ezisheshayo endleleni abanakekela ngayo izingane zabo.Ngokocwaningo lwango-2013, ngisho nokubambezeleka ekuhlolweni. inqubo yaholela ekufeni kwezingane ezithile.
Ukuhlolwa kwengane ngayinye kudinga amathiphu angu-30 kuya kwangu-40 ukuze kuqedelwe inqwaba yokuhlolwa kokuxilonga, futhi izinkulungwane zezingane zizalwa e-United States nsuku zonke.
Emuva ngoFebhuwari, ama-laboratories akwenza kwacaca ukuthi abanazo izinto abazidingayo.Ama-laboratories ezifundazweni ezingu-14 asesele namathiphu angaphansi kwenyanga, ngokusho kwe-Association for Public Health Laboratories.Iqembu likhathazeke kakhulu kangangokuthi ubelokhu ecindezela uhulumeni wobumbano, kuhlanganise ne-White House, izinyanga ukuthi abeke phambili isidingo samathiphu we-pipette wohlelo lokuhlola olusanda kuzalwa.Kuze kube manje, akukho okushintshile, iqembu lathi.I-White House itshele i-STAT ukuthi abaphathi babheka eziningana izindlela zokwandisa ukutholakala kwamathiphu.
Kwezinye izindawo, ukushoda kwepulasitiki “kucishe kwaholela ekuvalweni kwezinhlelo zokuhlola izingane ezisanda kuzalwa,” uSusan Tanksley, umphathi wophiko lwe-Laboratory Services Division yoMnyango Wezempilo waseTexas, etshela umhlangano weFederal Advisory Committee on Newborn Screening ngoFebhuwari.kusho.(UTankskey kanye nomnyango wezempilo wezwe abazange baphendule izicelo zokuphawula.)
UScott Shone, umqondisi weNorth Carolina Public Health Laboratory, uthe ezinye izifundazwe zithole inqwaba yamathiphu sekusele usuku olulodwa nje, zishiye bengenakwenza lutho ngaphandle kokucela ukusekelwa kwamanye amalebhu .USean uthe uzwile ezinye izikhulu zezempilo zomphakathi zifona “ ukuthi, 'Ngiphelelwa yimali kusasa, ungangitholela okuthile ngobusuku nje?'Ngoba umphakeli uthe iyeza, kodwa bengingakwazi lokho.’”
"Kholwa ukuthi uma lowo mthengisi ethi, 'Izinsuku ezintathu ngaphambi kokuthi uphelelwe, sizokunikeza enye inyanga' - ukukhathazeka lokho," esho.
Amalebhu amaningi aphendukele kwezinye izindlela esikhundleni sokukhohlisa amajaji.Ezinye ziyahlanzwa futhi ziphinde zisetshenziswe, okwandisa ingozi engaba khona yokutheleleka ngegciwane.Abanye benza ukuhlola okusanda kuzalwa ngamaqoqo, okungase kwandise isikhathi esisithathayo ukunikeza imiphumela.
Kuze kube manje, lezi zixazululo zanele.” Asikho esimweni lapho umntwana osanda kuzalwa esongelwa ngokushesha,” kusho u-Shone.
Ngaphezu kwamalabhorethri ahlola izingane ezisanda kuzalwa, izinkampani ze-biotech ezisebenza ekwelapheni okusha kanye nezindawo zokucwaninga zasenyuvesi ezisebenza ocwaningweni oluyisisekelo ziyazizwa zincane.
Ososayensi kwa-PRA Health Sciences, inhlangano yocwaningo lwenkontileka esebenza ekuhlolweni kwemitholampilo yesifo sokusha kwesibindi kohlobo B kanye nedlanzana labangenele imishanguzo iBristol Myers Squibb, bathi ukuncipha kwempahla kuwusongo oluqhubekayo - nakuba bengakubambezeli ngokusemthethweni ukufundwa.
"Ngezinye izikhathi, iphenduka ibe umugqa wamathiphu eshalofini elingemuva, futhi sifana 'oh nkosi yami,'" kusho u-Jason Neat, umqondisi omkhulu wezinsizakalo ze-bioanalytical e-PRA Health e-Kansas.
U-Kathleen McGinness, inhloko ye-RNA biology e-Arrakis Therapeutics, inkampani esebenza ngemithi engase ibe khona yomdlavuza, ukuphazamiseka kwemizwa kanye nezifo ezingavamile, udale isiteshi esizinikele se-Slack ukuze asize ozakwabo babelane ngolwazi.Isixazululo sokuvikela amathiphu e-pipette.
“Sibone ukuthi bekungeyona into engathi sína,” esho ngesiteshi se-#tipsfortips.” Abantu abaningi eqenjini bebematasa befuna izixazululo, kodwa besingenayo indawo eyinhloko yokwabelana ngalezo.”
Iningi lezinkampani ze-biotech i-STAT ekhulume nazo zathi zithatha izinyathelo zokuvikela ama-pipettes alinganiselwe futhi kuze kube manje azikayeki ukusebenza.
Isibonelo, ososayensi e-Octant bayakhetha kakhulu uma kuziwa ekusebenziseni amathiphu e-pipette ahlungiwe.Lawa mathiphu - obekunzima kakhulu ukuwathola kulezi zinsuku - ahlinzeka ngesendlalelo esengeziwe sokuvikela amasampula kukungcola kwangaphandle, kodwa awakwazi ukuvalwa inzalo futhi aphinde asetshenziswe. .Ngakho-ke, babanikeza ngokukhethekile imisebenzi engase ibe bucayi kakhulu.
“Uma ungakunaki okusebenzisayo, ungaphelelwa kalula,” kusho uDanielle de Jong, umphathi waselabhorethri eWhitney Laboratory eNyuvesi yaseFlorida, lapho eyingxenye yelebhu efunda ukuthi isiqu sinjani. amaseli asebenza ezilwaneni ezincane zasolwandle ezihlobene ne-jellyfish.Ngokusebenza, lezi zilwane zingakwazi ukukhiqiza kabusha izingxenye zazo.
Ososayensi baseWhitney Lab ngezinye izikhathi bakhipha ibheyili omakhelwane babo lapho ama-oda okunikezwayo engafiki ngesikhathi.de UJong waze wazithola esepequlula amashalofu kwamanye amalebhu ukuze athole noma yimaphi amathiphu angamapayipi angasetshenzisiwe uma ngabe ilebhu yakhe idinga ukuboleka.
“Sengihlale elebhu iminyaka engu-21,” kusho yena.”Angikaze ngibe nenkinga ye-supply chain njengale.Njalo.”
Ukuqhuma okungazelelwe kwangonyaka odlule kokuhlolwa kwe-Covid-19 - ngakunye okuncike kumathiphu e-pipette - ngokuqinisekile kunendima enkulu.
Ukunqamuka kukagesi ezweni lonke e-Texas kwabulala abantu abangaphezu kwe-100 futhi kwaphazamisa isixhumanisi esibalulekile se-pipette eyinkimbinkimbi. amathiphu we-pipette.
Isitshalo sendawo yase-Exxon's Houston besingumkhiqizi wesibili ngobukhulu enkampanini we-polypropylene ngo-2020, ngokusho kombiko kaMashi;imboni yayo yase-Singapore kuphela ekhiqize okwengeziwe.Izimboni ezimbili ze-polyethylene ezinkulu ezintathu ze-ExxonMobil nazo zitholakala e-Texas.(Ngo-April 2020, i-ExxonMobil yaze yanyusa ukukhiqizwa kwe-polypropylene ezitshalweni ezimbili zase-US.)
“Ngemva kweziphepho zasebusika ngo-February walo nyaka, kulinganiselwa ukuthi ngaphezu kuka-85% umthamo we-polypropylene e-United States iye yaphazanyiswa izinkinga ezihlukahlukene ezinjengokuqhuma kwamapayipi, ukunqamuka kukagesi nokunqamuka kukagesi ezikhungweni ezikhiqizayo.Impahla ebalulekile edingekayo ukuze kuqalwe kabusha ukukhiqiza,” kusho omunye umkhiqizi we-polypropylene.Okhulumela inkampani kawoyela negesi ezinze eHouston, iTotal.
Kodwa amaketanga okunikezwayo abe ngaphansi kwengcindezi kusukela ehlobo eledlule - ngaphambi kokuba kube yiqhwa okujulile ngoFebhuwari. Amazinga aphansi kunejwayelekile ezinto zokusetshenziswa akuzona kuphela izinto ezivimbela ukuthengwa kwempahla—futhi akuwona amathiphu e-pipette okuwukuphela kwemishini yelebhu yepulasitiki entulekayo. .
Umlilo wemboni yokukhiqiza uphinde waphazamisa ukuhlinzekwa kwamaphesenti angama-80 amakhonteyina ezwe amathiphu e-pipette asetshenzisiwe nezinye izinto ezibukhali, ngokombhalo ofakwe kusizindalwazi seNyuvesi yasePittsburgh.
NgoJulayi, i-US Customs and Border Protection yaqala ukuvimba imikhiqizo evela kumenzi omkhulu wamagilavu osolwa ngokusebenza ngempoqo.(I-CBP ikhiphe imiphumela yayo ngenyanga edlule.)
"Esikubonayo ngempela ukuthi ibhizinisi elihlobene namapulasitiki - i-polypropylene ikakhulukazi - liphelile noma lidingeka kakhulu," kusho i-PRA Health Sciences' Neat.
Isidingo siphezulu kangangokuthi amanani entengo yezinto eziyivelakancane akhuphuke, kusho uTiffany Harmon, umqondisi wokuthengwa kwempahla e-PRA Health Sciences 'bioanalytical laboratory eKansas.
Manje inkampani ikhokha u-300% ngaphezulu wamagilavu ngokusebenzisa abahlinzeki bayo abavamile.Ama-oda we-pipette we-PRA aseyatholakala ukuze akhokhe imali eyengeziwe.Umkhiqizi wamathiphu e-pipette, ngenyanga edlule wamemezela inhlawulo entsha engamaphesenti angu-4.75, utshele amakhasimende ayo ukuthi ukuthutha kwakudingeka ngoba intengo yezinto zokusetshenziswa zepulasitiki icishe yaphindeka kabili.
Okwenezela ekungabazeni kososayensi baselabhu inqubo abasakazi abanquma ngayo ukuthi imaphi ama-oda azogcwaliswa kuqala—bambalwa ososayensi abathi baqonda ngokugcwele ukuthi lokhu kusebenza kanjani.
"Umphakathi waselabhu ucele kwasekuqaleni ukuthi usisize siqonde ukuthi lezi zinqumo zenziwa kanjani," kusho u-Shone, obiza abathengisi befomula abasebenzisa ukunquma izabelo ngokuthi "umlingo webhokisi elimnyama."
I-STAT ithinte izinkampani ezingaphezu kweshumi nambili ezikhiqiza noma ezithengisa amathiphu e-pipette, okuhlanganisa i-Corning, i-Eppendorf, i-Fisher Scientific, i-VWR ne-Rainin. Zimbili kuphela izimpendulo.
U-Corning wenqabile ukuphawula, ecaphuna izivumelwano zokuphathelene namakhasimende.
"Isidingo semikhiqizo ehlobene ne-Covid-19, okubandakanya iMilliporeSigma, ibingakaze ibonwe embonini yesayensi yezempilo kusukela kwaqala lolu bhubhane," umkhulumeli wenkampani enkulu esabalalisa izinto zesayensi utshele i-STAT esitatimendeni esithunyelwe nge-imeyili. /7 ukuhlangabezana nesidingo esikhulayo sale mikhiqizo naleyo esetshenziselwa ukutholwa kwesayensi. "
Naphezu kwemizamo yokuqinisa amaketanga okuhlinzeka, akucaci ukuthi ukushoda kuzohlala isikhathi esingakanani.
U-Corning uthole u-$15 wezigidi ezivela eMnyangweni Wezokuvikela wase-US ukuze akhiqize amanye amathiphu angama-pipette ayizigidi ezingu-684 minyaka yonke endaweni yawo e-Durham, eNyakatho Carolina.I-Tecan isebenzisa futhi i-CARES Act's $32 million ukwakha indawo entsha yokukhiqiza.
Kodwa lokho ngeke kuxazulule inkinga uma ukukhiqizwa kwepulasitiki kuhlala kuphansi kunalokho okulindelekile.Kunoma yikuphi, ayikho kulawa maphrojekthi ezokwazi ukukhiqiza amathiphu e-pipette ekwindla ka-2021.
Kuze kube yileso sikhathi, abaphathi bamalebhu nososayensi babhekela ukushoda okwengeziwe kwama-pipettes nanoma yini enye.
“Siqale lolu bhubhane ngaphandle kwama-swabs nangaphandle kwabezindaba.Sabe sesiba nokushoda kwama-reagents.Sabe sesishoda opulasitiki.Bese kuba nokushoda kwama-reagents, ”kusho uShone waseNorth Carolina.
Isibuyekezo: Ngemva kokuba le ndaba ishicilelwe, i-MilliporeSigma yachaza ukuthi isebenzisa uhlelo olufika kuqala, olunikezwa kuqala ukuze lukhiphe amathiphu e-pipette, kunesistimu yezendlalelo ezine eyachazwa ekuqaleni.Le ndaba manje ibonisa isibuyekezo enkampanini.
U-Kate uqoqa futhi ahlaziye imibhalo, idatha nolunye ulwazi lwe-biotech, ubuchwepheshe bezempilo, isayensi nezindaba zezombusazwe.
Kate, lesi isihloko esihle kakhulu sokugcina wonke umuntu azi mayelana nalezi zinselelo ezinkulu eziqhubekayo ze-supply chain embonini. Ngithanda ukwabelana nawe ukuthi i-Grenova (www.grenovasolutions.com) iziqhenye ngokuhlinzeka ngamalabhorethri ngezisombululo ezifakazelwe nezisimeme futhi ibambe iqhaza ekubhekaneni nokushoda kwamathiphu e-pipette ezimakethe zaselabhorethri ze-COVID nezingezona i-COVID zidlale indima ebalulekile ngo-2020. kuholele ekuncipheni okungaphezu kuka-90% kwezimfuneko zethiphu ye-pipette kanye nokwehliswa okukhulu kwezindleko kanye nemfucumfucu yepulasitiki.Silapha ukuze sisekele imboni futhi sazise wonke amalebhu ukuthi i-Grenova inesixazululo esimeme kakhudlwana sochungechunge lokuhlinzeka ngamathiphu we-pipette. Abazithobayo, UMongameli we-Ali Safavi kanye ne-CEO iGrenova, Inc.
Wow.Wonke usokhemisi waselabhu cishe uwenza ngamashubhu engilazi (bamba ishubhu ekugcineni ngakunye, fudumeza phakathi nendawo kumshini wokushisa we-bunson, donsa kancane...phuma kushishi…thola amapayipi amabili ngokushesha). ikhombisa iminyaka yami...
Isikhathi sokuthumela: May-24-2022