Tushen pipette mai ƙasƙantar da kai ƙarami ne, mara tsada, kuma yana da mahimmanci ga kimiyya.Yana ba da ikon bincike kan sabbin magunguna, cututtukan Covid-19 da kowane gwajin jini.
Amma yanzu, jerin rikice-rikicen da ba su dace ba a cikin sarkar samar da bututun saboda katsewar wutar lantarki, gobara da buƙatun da ke da alaƙa da cutar sun haifar da ƙarancin duniya wanda ke yin barazana ga kusan kowane ɓangarorin masana kimiyya.
Karancin tukwici na pipette ya kawo cikas ga shirin a duk faɗin ƙasar don tantance jariran da ke da haɗari masu haɗari, kamar rashin iya narkewar sukari a cikin madarar nono.Yana barazana ga gwajin ƙwayoyin halittar ƙwayoyin ƙwayoyin cuta na jami'a. Hakanan ya tilasta kamfanonin fasahar kere kere da ke aiki kan haɓaka sabbin magunguna suyi la'akari da su. fifita wasu gwaje-gwaje akan wasu.
A yanzu, babu alamar ƙarancin zai ƙare kowane lokaci nan ba da jimawa ba - idan abubuwa suka yi muni, masana kimiyya na iya fara jinkirin gwaje-gwaje ko ma yin watsi da wasu ayyukansu.
"Ra'ayin samun damar yin kimiyya ba tare da su ba abin kunya ne," in ji Gabrielle Bostwick, manajan dakin gwaje-gwaje a Octant Bio, wani farawar nazarin halittun roba na tushen California.
Daga cikin dukkan masana kimiyyar da ke nuna bacin rai game da karancin, masu binciken da aka dorawa alhakin tantance jarirai sun fi tsari da bayyana ra'ayi.
Dakunan gwaje-gwajen kiwon lafiyar jama'a suna bincikar jarirai don yawancin cututtukan ƙwayoyin cuta a cikin sa'o'i na haihuwa. Wasu, irin su phenylketonuria da rashi na MCAD, suna buƙatar likitoci su yi canje-canje nan da nan kan yadda suke kula da jariransu. A cewar wani bincike na 2013, har ma da jinkiri a cikin tantancewar. tsari ya haifar da mutuwar wasu jarirai.
Nuna kowane yaro yana buƙatar kusan shawarwarin pipette 30 zuwa 40 don kammala gwaje-gwajen bincike da yawa, kuma ana haihuwar dubban yara a Amurka kowace rana.
Komawa cikin watan Fabrairu, dakunan gwaje-gwajen sun bayyana karara cewa ba su da kayayyakin da suke bukata.Dakunan gwaje-gwaje a cikin jihohi 14 suna da ragowar tukwici na pipette kasa da wata guda, a cewar kungiyar dakunan gwaje-gwajen lafiyar jama'a. Kungiyar ta damu matuka da hakan. ta dade tana matsawa gwamnatin tarayya, ciki har da fadar White House, tsawon watanni don ba da fifiko ga bukatar shawarwarin pipette don shirin tantance jarirai.Ya zuwa yanzu, babu abin da ya canza, in ji kungiyar. Fadar White House ta shaida wa STAT cewa gwamnatin na duba da dama. hanyoyin da za a ƙara tip samuwa.
A wasu hukunce-hukuncen, karancin filastik “kusan ya haifar da rufe wasu shirye-shiryen tantance jarirai,” Susan Tanksley, manajan sashen Sashen Sabis na Laboratory Services na Ma'aikatar Lafiya ta Texas, ta fadawa taron Kwamitin Ba da Shawarwari na Tarayya kan Binciken Jarirai a watan Fabrairu.yace.(Tankskey da ma'aikatar lafiya ta jihar ba su amsa buƙatun don yin tsokaci ba.)
Scott Shone, darektan dakin gwaje-gwajen kiwon lafiyar jama'a na North Carolina, ya ce wasu jihohin sun sami tarin shawarwari saura kwana daya, wanda hakan ya sa ba su da wani zabi illa neman tallafi daga wasu dakunan gwaje-gwaje.Sean ya ce ya ji wasu jami'an kiwon lafiyar jama'a suna kiran " a ce, 'Kudi na ƙarewa gobe, za ku iya samun wani abu a cikin dare?'Domin mai sayar da kayayyaki ya ce yana zuwa, amma ban san hakan ba.'
"Ku yi imani cewa lokacin da mai sayar da kayayyaki ya ce, 'Kwana uku kafin ku ƙare, za mu ba ku wata-wata' - wannan damuwa ne," in ji shi.
Yawancin dakunan gwaje-gwaje sun juya zuwa madadin juri magudi.Wasu ana tsaftace su kuma an sake amfani da su, suna ƙara haɗarin kamuwa da cuta.
Ya zuwa yanzu, wadannan mafita sun wadatar.” Ba mu cikin wani yanayi da ake yi wa jariri barazana nan da nan,” Shone ya kara da cewa.
Baya ga dakunan gwaje-gwaje na tantance jarirai, kamfanonin fasahar kere-kere da ke aiki kan sabbin jiyya da dakunan gwaje-gwajen jami'o'i da ke aiki kan bincike na asali suna jin duriyarsu.
Masana kimiyya a Kimiyyar Kiwon Lafiya ta PRA, ƙungiyar bincike ta kwangila da ke aiki kan gwajin asibiti na cutar hanta B da kuma da yawa daga cikin 'yan takarar magunguna na Bristol Myers Squibb, sun ce raguwar wadatar barazana ce mai gudana - kodayake ba su jinkirta kowane karatu a hukumance ba.
Jason Neat, babban darektan sabis na nazarin halittu a Lafiya ta PRA a Kansas ya ce "Wani lokaci, yana juya zuwa jeri na tukwici akan shiryayye na baya, kuma muna kama da 'oh my gosh'.
Kathleen McGinness, shugaban nazarin halittu na RNA a Arrakis Therapeutics, kamfanin da ke aiki akan yiwuwar jiyya don ciwon daji, cututtuka na jijiyoyi da cututtuka masu wuyar gaske, ya kirkiro tashar Slack mai sadaukarwa don taimakawa abokan aikinta su raba bayanai. Magani don kare shawarwarin pipette.
"Mun fahimci hakan ba da gaske ba ne," in ji ta na tashar #tipsfortips. "Mutane da yawa a cikin ƙungiyar suna neman mafita sosai, amma ba mu da wurin da za mu raba waɗancan."
Yawancin kamfanonin fasahar kere kere ta STAT sun zanta da su, sun ce suna daukar matakan kare iyakokin bututun mai kuma kawo yanzu ba su daina aiki ba.
Alal misali, masana kimiyya a Octant suna da kyau sosai idan aka zo amfani da shawarwarin pipette da aka tace.Wadannan shawarwari - waɗanda suka kasance da wuya a zo a kwanakin nan - suna ba da ƙarin kariya ga samfurori daga gurɓataccen waje, amma ba za a iya haifuwa da sake amfani da su ba. .Saboda haka, sun ƙware su don ayyukan da ka iya zama masu mahimmanci.
Danielle de Jong, manajan dakin gwaje-gwaje a dakin gwaje-gwaje na Whitney da ke Jami'ar Florida ta ce "Idan ba ku kula da abin da kuke amfani da shi ba, za ku iya guduwa cikin sauki," in ji Danielle de Jong, manajan dakin gwaje-gwaje a dakin gwaje-gwaje na Whitney a Jami'ar Florida, inda take wani bangare na dakin gwaje-gwajen da ke nazarin yadda itacen itace. Kwayoyin suna aiki a cikin ƙananan dabbobin ruwa masu alaƙa da jellyfish.Aiki, waɗannan dabbobin na iya sake haɓaka sassan kansu.
Masana kimiyya a Whitney Lab wani lokaci suna ba da belin maƙwabtansu lokacin da odar ba ta isa ba.
"Na kasance a cikin dakin gwaje-gwaje na tsawon shekaru 21," in ji ta. "Ban taɓa samun matsalar sarkar kayayyaki kamar wannan ba.Har abada."
Fashewar gwajin kwatsam na shekarar da ta gabata na gwajin Covid-19 - kowannensu ya dogara da shawarwarin pipette - tabbas ya taka rawa.Amma illar bala'o'i da sauran abubuwan da ba a saba gani ba a cikin sarkar samar da kayayyaki suma sun zube kan benci na lab.
Wata mummunar katsewar wutar lantarki a jihar Texas ta kashe mutane sama da 100 tare da tarwatsa wata hanyar sadarwa mai sarkakiya a cikin sarkar samar da bututun mai. Kashewar ta tilasta wa Exxon da sauran kamfanoni rufe masana'antu a jihar na wani dan lokaci - wasu daga cikinsu suna yin resin polypropylene, albarkatun kasa. pipette tukwici.
Kamfanin Exxon na yankin Houston shine kamfani na biyu mafi girma na polypropylene a cikin 2020, a cewar rahoton Maris;Kamfaninsa na Singapore ne kawai ya samar da ƙarin. Biyu daga cikin manyan shuke-shuken polyethylene uku na ExxonMobil suma suna cikin Texas.
“Bayan guguwar hunturu a watan Fabrairun bana, an kiyasta cewa sama da kashi 85% na karfin polypropylene da ke Amurka ya yi mummunar illa sakamakon matsaloli iri-iri kamar fasa bututun mai, katsewar wutar lantarki, da katsewar wutar lantarki a masana’antar kera.Wani muhimmin danyen abu da ake buƙata don sake farawa samarwa, ”in ji wani mai samar da polypropylene.Mai magana da yawun kamfanin mai da iskar gas Total da ke Houston ya ce.
Amma sarƙoƙi suna fuskantar matsin lamba tun lokacin rani na ƙarshe - da kyau kafin daskare mai zurfi a cikin Fabrairu. Matakan albarkatun ƙasa fiye da na yau da kullun ba shine kawai abin da ke hana sarƙoƙi ba - kuma ba buƙatun pipette ne kawai kayan aikin lab ɗin filastik a takaice. .
Gobarar da ta tashi a masana'antar ta kuma kawo cikas wajen samar da kashi 80 cikin 100 na kwantenan da aka yi amfani da su na bututun bututu da sauran kaifi, a cewar wata takarda da aka buga a shafin intanet na Jami'ar Pittsburgh.
A watan Yuli, Hukumar Kwastam da Kariya ta Amurka ta fara toshe kayayyaki daga wani babban mai kera safar hannu da ake zargi da yin aikin tilas.(CBP ta fitar da sakamakon bincikensa a watan jiya.)
"Abin da muke gani da gaske shine kasuwancin da ke da alaƙa da robobi - musamman polypropylene - ko dai ya ƙare ko kuma yana cikin buƙatu mai yawa," in ji PRA Health Sciences' Neat.
Bukatu ya yi yawa har farashin wasu ƙarancin kayayyaki ya tashi, in ji Tiffany Harmon, mai kula da sayayya a dakin gwaje-gwajen halittu na PRA Health Sciences a Kansas.
Kamfanin yanzu yana biyan ƙarin 300% na safar hannu ta hanyar masu ba da sabis na yau da kullun. Ana samun odar pipette na PRA a yanzu don ƙarin kuɗi. Wani mai kera na'urorin pipette, wanda a watan da ya gabata ya sanar da ƙarin ƙarin ƙarin kashi 4.75 cikin ɗari, ya gaya wa abokan cinikinsa cewa matakin ya zama dole. saboda farashin albarkatun robobi ya kusan rubanya.
Ƙara zuwa rashin tabbas ga masana kimiyyar dakin gwaje-gwaje shine tsarin da masu rarrabawa ke tantance ko wane umarni ne za a fara cika-kaɗan masana kimiyya sun ce sun fahimci yadda wannan ke aiki sosai.
Shone, wanda ya kira tsarin da masu siyar da kayayyaki ke amfani da shi don tantance rabon "sihirin akwatin akwatin."
STAT ta tuntubi kamfanoni fiye da dozin guda waɗanda ke kerawa ko siyar da shawarwarin pipette, gami da Corning, Eppendorf, Fisher Scientific, VWR da Rainin. Amsoshi biyu ne kawai.
Corning ya ki yin tsokaci, yana ambaton yarjejeniyar mallakar mallaka tare da abokan ciniki. A halin yanzu, MilliporeSigma ya ce yana ba da pipettes a kan hanyar da ta fara zuwa.
"Buƙatar samfuran da ke da alaƙa da Covid-19, gami da MilloporeSigma, ba a taɓa ganin irinsa ba a cikin masana'antar kimiyyar rayuwa tun farkon barkewar cutar," in ji mai magana da yawun babban kamfanin rarraba kayayyakin kimiya na kimiyya ga STAT a cikin wata sanarwa ta imel. "Muna aiki 24. / 7 don saduwa da karuwar buƙatun waɗannan samfuran da waɗanda aka yi amfani da su don binciken kimiyya.
Duk da yunƙurin ƙarfafa hanyoyin samar da kayayyaki, ba a san tsawon lokacin da ƙarancin zai dawwama ba.
Corning ya karɓi dala miliyan 15 daga Ma'aikatar Tsaro ta Amurka don samar da ƙarin tukwici na pipette miliyan 684 a kowace shekara a wurinta a Durham, North Carolina. Tecan kuma yana amfani da Dokar CARES ta dala miliyan 32 don gina sabon masana'anta.
Amma wannan ba zai magance matsalar ba idan samar da filastik ya kasance ƙasa da yadda ake tsammani. A kowane hali, babu ɗayan waɗannan ayyukan da za su iya samar da tukwici na pipette ta faɗuwar 2021.
Har zuwa lokacin, manajojin dakin gwaje-gwaje da masana kimiyya suna yin ƙarfin gwiwa don ƙarin ƙarancin pipettes da kowane abu.
"Mun fara wannan cutar ba tare da swabs ba kuma ba tare da kafofin watsa labarai ba.Sannan muna da karancin reagents.Sannan mun sami karancin robobi.Sannan muna da karancin masu sakewa," in ji Shone na North Carolina. "Kamar Ranar Groundhog ce."
Sabuntawa: Bayan da aka buga wannan labarin, MilliporeSigma ya bayyana cewa yana amfani da tsarin da aka fara zuwa, wanda aka fara amfani da shi don ba da shawarwarin pipette, maimakon tsarin Layer hudu wanda aka kwatanta da farko. Wannan labarin yanzu yana nuna sabuntawa akan kamfanin.
Kate tana tattarawa da nazarin takardu, bayanai da sauran bayanai don fasahar kere-kere, fasahar kiwon lafiya, kimiyya da labarun siyasa.
Kate, wannan babban labarin ne don sanar da kowa game da waɗannan manyan kalubalen sarkar samar da kayayyaki da ke gudana a cikin masana'antar. Ina so in raba tare da ku cewa Grenova (www.grenovasolutions.com) ya yi alfaharin samar da dakunan gwaje-gwaje tare da ingantattun mafita da dorewa. ya taka rawa wajen magance karancin shawarwarin pipette a cikin COVID kuma kasuwannin dakin gwaje-gwaje marasa COVID sun taka muhimmiyar rawa a cikin 2020. A cikin dakunan gwaje-gwaje da ke aiwatar da Grenova Tip Washers, an wanke kowane tip ɗin pipette kuma an sake amfani da shi fiye da sau 15 akan matsakaici. ya haifar da raguwa fiye da 90% a cikin buƙatun buƙatun pipette da raguwa mai yawa a cikin farashi da sharar filastik. Muna nan don tallafawa masana'antu kuma mu sanar da duk labs cewa Grenova yana da mafita mai ɗorewa ga tsarin samar da tip pipette.Gaskiya, Ali Safavi Shugaba da Shugaba Grenova, Inc.
Wow. Kowane lab chemist mai yiwuwa ya sa su fita daga gilashin tubes (riƙe tube a kowane karshen, zafi tsakiyar a kan bunson burner, ja sannu a hankali ... fita daga cikin burner ... samun 2 pipettes da sauri).Ba ni da tabawa kuma nuna shekaruna…
Lokacin aikawa: Mayu-24-2022