Iyo yakazvininipisa pipette tipi idiki, isingadhure, uye yakakosha kusainzi.Inopa simba kutsvagisa mumishonga mitsva, Covid-19 kuongororwa uye kwese kweropa kuongororwa.
Asi ikozvino, nhevedzano yekukanganisa kusingatarisirwe mupipette tip yekugovera cheni nekuda kwekudzimwa kwemagetsi, moto uye zvichemo zvine chekuita nedenda zvakagadzira kushomeka kwepasirese kunotyisidzira ingangoita makona ese enharaunda yesainzi.
Kushaikwa kwemazano epipette kwakaisa pangozi chirongwa chenyika yose chekuongorora vana vachangoberekwa zvirwere zvinogona kuuraya, zvakadai sekutadza kugaya shuga iri mumukaka wezamu.Iri kutyisidzira yunivhesiti stem cell genetics experiments.Zvinomanikidzawo makambani ebiotech ari kushanda mukugadzira mishonga mitsva yekufunga. kukoshesa zvimwe zviedzo pane zvimwe.
Parizvino, hapana chiratidzo chekuti kushomeka kuchapera chero nguva munguva pfupi - kana zvinhu zvikawedzera, masayendisiti anogona kutanga kunonoka kuyedza kana kusiya rimwe rebasa ravo.
"Pfungwa yekukwanisa kuita sainzi pasina ivo inotosvora," akadaro Gabrielle Bostwick, maneja werabhoritari kuOctant Bio, yeCalifornia-based synthetic biology yekutanga.
Pamasayendisiti ese akagumbuka pamusoro pekushomeka, vaongorori vakapihwa basa rekuongorora vacheche ndivo vakarongeka uye vanotaura pachena.
MaLebhu ezvehutano everuzhinji anoongorora vacheche zvirwere zvakawanda zvemajini mukati memaawa ekuzvara. Zvimwe, zvakaita se phenylketonuria nekushomeka kweMCAD, zvinoda kuti vanachiremba vachinje nekukurumidza pamatarisiro avanoita vana vavo. Maererano neongororo ya2013, kunyange kunonoka mukuongororwa. nzira yakakonzera kufa kwevacheche.
Kuongororwa kwemwana wega wega kunoda matipi makumi matatu kusvika makumi mana ekuti apedze ongororo dzakawanda dzekuongorora, uye zviuru zvevana zvinozvarwa muUnited States mazuva ese.
Kudzoka muna Kukadzi, maLab akajekesa kuti vakanga vasina zvinhu zvavanoda.Marabhoritari mumatunhu gumi nemana ane matipi epipette asingasviki mwedzi asara, maererano neAssociation for Public Health Laboratories.Boka iri riri kunetsekana zvekuti yave ichimanikidza hurumende yemubatanidzwa, kusanganisira White House, kwemwedzi kuti itarise kudiwa kwepipette matipi echirongwa chekuongorora achangozvarwa.Kusvika parizvino, hapana chakachinja, boka rakadaro.White House yakaudza STAT kuti manejimendi ari kutarisa akati wandei. nzira dzekuwedzera matipi kuwanikwa.
Mune dzimwe nzvimbo, kushomeka kwepurasitiki "zvakapotsa zvakonzera kuvharwa kwezvimwe zvirongwa zvekuvheneka vachangozvarwa," Susan Tanksley, maneja wedhipatimendi reTexas Department of Health's Laboratory Services Division, akaudza musangano weFederal Advisory Committee on Newborn Screening muna Kukadzi.akadaro.(Tankskey uye dhipatimendi rezvehutano rehurumende havana kupindura zvikumbiro zvekutaura.)
Scott Shone, director weNorth Carolina Public Health Laboratory, akati dzimwe nyika dzakagamuchira batch yematipi kwasara zuva rimwe chete, zvichivasiya vasina chekuita kunze kwekukumbira rutsigiro kubva kune mamwe maLab. kuti, 'Ndiri kushaya mari mangwana, mungandiwanira chimwe chinhu usiku hwose here?'Nokuti mutengesi akati yaiuya, asi handina kuzviziva.’”
"Tenda kuti kana mutengesi akati, 'Mazuva matatu usati wapera, tichakupa imwe mwedzi yekutenga' - ndiko kunetseka," akadaro.
MaLab akawanda akatendeukira kune dzimwe nzira dzekutonga kwejury manipulation.Mamwe anocheneswa uye anoshandiswazve, zvichiwedzera njodzi inogona kuitika yekusvibiswa.Vamwe vari kuita vachangobva kuzvarwa kuongororwa mumabhechi, izvo zvinogona kuwedzera nguva inotora kupa mhedzisiro.
Kusvika pari zvino, mhinduro idzi dzakakwana.” Hatisi mumamiriro ezvinhu apo mwana achangoberekwa anotyisidzirwa pakarepo,” Shone akawedzera.
Pamusoro pemarabhoritari anoongorora vana vachangozvarwa, makambani ebiotech anoshanda pakurapa kutsva uye marabhoritari emayunivhesiti ari kushanda patsvakiridzo yepakutanga ari kunzwa kushomeka.
Masayendisiti kuPRA Health Sayenzi, sangano rekutsvagisa kondirakiti rinoshanda mukuyedzwa kwechipatara chehepatitis B uye vakati wandei Bristol Myers Squibb vakwikwidzi vezvinodhaka, vanoti kuderera kwekupa kuri kuramba kuchityisidzira - kunyangwe vasina kunonoka zviri pamutemo kuverenga.
"Dzimwe nguva, inoshanduka kuita mutsara wemazano pasherufu yekumashure, uye isu takaita senge 'nhai zvangu,'" akadaro Jason Neat, director director webioanalytical services paPRA Health muKansas.
Kathleen McGinness, mukuru weRNA biology kuArrakis Therapeutics, kambani inoshanda pakurapwa kwegomarara, chirwere chetsinga uye zvirwere zvisingawanzoitiki, yakagadzira nzira yakatsaurirwa yeSlack kubatsira vamwe vake kugovana ruzivo.Solution kuchengetedza pipette mazano.
"Takaona kuti zvainge zvisina kunetsa," akadaro nezve #tipsfortips chiteshi." Vanhu vazhinji pachikwata vaitsvaga mhinduro, asi isu takanga tisina nzvimbo yepakati yekugovera idzo.
Mazhinji emakambani ebiotech STAT akataura nawo akati vari kutora matanho ekudzivirira mapipette mashoma uye kusvika parizvino havana kumira kushanda.
Semuyenzaniso, masayendisiti kuOctant anonyanya kusarudza kana zvasvika pakushandisa yakasefa pipette matipi.Mazano aya - ayo anga akanyanya kuoma kuuya nemazuva ano - anopa imwe danho redziviriro yemasampuli kubva kune kunze kwetsvina, asi haigone kuvharirwa uye kushandiswa zvakare. .Nokudaro, vanovapa mazvikokota ezviitwa zvingangonyanya kunetsa.
"Kana ukasateerera zvaunoshandisa, unogona kupera nyore," anodaro Danielle de Jong, maneja werabhoritari paWhitney Laboratory paYunivhesiti yeFlorida, uko ari chikamu cherabhoritari inodzidza mabvi. masero anoshanda mumhuka diki dzemugungwa dzine chekuita nejellyfish.Kushanda, mhuka idzi dzinogona kuvandudza zvikamu zvadzo.
Masayendisiti epaWhitney Lab dzimwe nguva anobvisa vavakidzani vavo kana maodha asingasviki nenguva.
“Ndave ndiri murabhoritari kwemakore 21,” akadaro.” Handisati ndambova nechinetso chechain chain chakadai.Nguva dzose.”
Kuputika kwakangoerekana kwaitika kwegore rapfuura kweCovid-19 bvunzo - imwe neimwe ichitsamira pamapipette matipi - zvirokwazvo yakaita basa.
Kudzimwa kwemagetsi munyika yose muTexas kwakauraya vanhu vanopfuura zana uye kwakakanganisa chinongedzo chepipette yakaoma. Kubuda kwakamanikidza Exxon nemamwe makambani kuvhara kwenguva pfupi mafekitori muhurumende - mamwe acho anogadzira polypropylene resin, iyo mbishi pipette mazano.
Exxon's Houston-nzvimbo chirimwa yaive yechipiri pakukura mugadziri wepolypropylene muna 2020, sekureva kwaKurume chirevo;chirimwa chayo chekuSingapore chete chakagadzira zvimwe. Zviviri zvezvimiti zvitatu zvakakura zvepolyethylene zveExxonMobil zvinowanikwawo muTexas.(Muna Kubvumbi 2020, ExxonMobil yakatowedzera kugadzirwa kwepolypropylene pazvimera zviviri zvekuUS.)
“Pashure pemadutu echando muna Kukadzi gore rino, zvinofungidzirwa kuti chikamu chinodarika 85% chepolypropylene muUnited States chakakanganiswa nezvinetso zvakasiyana-siyana zvakadai sekuputika kwepombi, kudzimwa kwemagetsi, uye kudzimwa kwemagetsi panzvimbo dzinogadzirwa.Chinhu chakakosha chinodiwa kutangazve kugadzira, ”akadaro mumwe mugadziri wepolypropylene.Mutauriri weHouston-based oil and gas company Total akadaro.
Asi cheni dzekugovera dzave dziri pasi pekumanikidzwa kubva muzhizha rapfuura - nguva isati yanyanya kutonhora muna Kukadzi. Yakaderera-kupfuura-yakajairika mazinga emidziyo haisi iyo chete chinhu chinomanikidza kugovera cheni-uye haisi iyo pipette matipi ndiyo chete yepurasitiki lab midziyo mupfupi. .
Moto wekudyara wekugadzira wakakanganisawo kupihwa kwe80 muzana yemidziyo yenyika yakashandiswa matipi epipetti uye zvimwe zvinopinza, sekureva kwegwaro rakatumirwa pawebhusaiti yeYunivhesiti yePittsburgh.
Muna Chikunguru, US Customs and Border Protection yakatanga kuvharira zvigadzirwa kubva kune anogadzira magirovhosi makuru anofungidzirwa kuti aishanda nechibharo.(CBP yakaburitsa zvayakawana mwedzi wapera.)
"Zvatiri kunyatsoona ndezvekuti bhizinesi rine chekuita nemapurasitiki - polypropylene kunyanya - rave kupera muzvitoro kana kudiwa zvakanyanya," akadaro PRA Health Sayenzi 'Neat.
Kudiwa kwakakwira zvekuti mitengo yezvimwe zvinhu zvinoshomeka yakakwira, akadaro Tiffany Harmon, maneja wekutenga zvinhu paPRA Health Sciences 'bioanalytical laboratory muKansas.
Iyo kambani ikozvino inobhadhara 300% mamwe magirovhosi kuburikidza neayo emazuva ese vatengesi.PRA's pipette tip mirairo yave kuwanikwa kune imwezve mari.Mugadziri wemapipette tips, uyo mwedzi wapera akazivisa kubhadharisa kutsva kwe4.75 muzana, akaudza vatengi vayo kutama kwaidiwa. nekuti mutengo wemidziyo yepurasitiki wawedzera zvakapetwa kaviri.
Kuwedzera kusavimbika kwemasaenzi eLab inzira iyo vanogovera vanoona kuti ndeapi maodha anotanga kuzadzwa - vashoma vesainzi vanoti vanonzwisisa zvizere kuti izvi zvinoshanda sei.
"Nharaunda yevashandi yakabvunza kubva pakutanga kuti itibatsire kunzwisisa kuti sarudzo idzi dzinoitwa sei," akadaro Shone, uyo anodana mafomula anoshandiswa nevatengesi kuona kugoverwa kwe "black-box magic."
STAT yakabata makambani anopfuura gumi nemaviri anogadzira kana kutengesa matipi epipette, anosanganisira Corning, Eppendorf, Fisher Scientific, VWR uye Rainin. Pane mhinduro mbiri chete.
Corning yakaramba kutaura, ichitaura zvibvumirano zvekutengesa nevatengi.Zvichakadaro, MilliporeSigma yakati inopa pipettes pane yekutanga-kuuya, yekutanga-yakashandiswa.
"Kudiwa kwezvigadzirwa zvine chekuita neCovid-19, zvinosanganisira MilliporeSigma, kwanga kusati kwamboitika muindasitiri yesainzi yehupenyu kubva pakatanga denda," mutauriri wekambani huru yekugovera zvesainzi akaudza STAT mutsamba ine email." Tiri kushanda makumi maviri nemana. /7 kuzadzisa kudiwa kuri kukura kwezvinhu izvi uye izvo zvinoshandiswa kuwanikwa kwesainzi. "
Pasinei nekuedza kusimbisa cheni dzekugovera, hazvizivikanwe kuti kushomeka kuchagara kwenguva yakareba sei.
Corning yakagamuchira mamiriyoni gumi nemashanu emadhora kubva kuUnited States Department of Defence kuti igadzire mamwe 684 miriyoni pipette matipi pagore panzvimbo yayo muDurham, North Carolina.Tecan iri kushandisawo CARES Act's $32 miriyoni kuvaka nzvimbo itsva yekugadzira.
Asi izvo hazvigadzirise dambudziko kana kugadzirwa kwepurasitiki kukaramba kwakadzikira pane zvakatarisirwa. Chero zvazvingava, hapana chimwe chezvirongwa izvi chichakwanisa kuburitsa matipi epipette pakupera kwa2021.
Kusvika panguva iyoyo, mamaneja emalabhu nemasainzi vari kutsvaga kushomeka kwepipette uye chero chinhu.
“Takatanga denda iri tisina swabs uye tisina midhiya.Ipapo takava nekushomeka kwemareagents.Ipapo takava nekushomeka kwemapurasitiki.Ipapo takava nekushomeka kwemareagents, ”akadaro Shone wekuNorth Carolina.” Zvakafanana neZuva reGroundhog.
Update: Mushure mokunge nyaya iyi yabudiswa, MilliporeSigma yakatsanangura kuti inoshandisa yekutanga-kuuya, yekutanga-yakashandiswa hurongwa hwekupa mazano epipette, panzvimbo yechina-layer system iyo yakatsanangura pakutanga.Nyaya iyi ikozvino inoratidza update pamusoro pekambani.
Kate anounganidza uye anoongorora magwaro, data uye rumwe ruzivo rwebiotech, hutano tech, sainzi uye nyaya dzezvematongerwo enyika.
Kate, ichi chinyorwa chakanakisa chekuchengeta munhu wese achiziva nezveaya makuru arikuenderera mberi ekutengesa cheni matambudziko muindasitiri.Ndinoda kugovana newe kuti Grenova (www.grenovasolutions.com) yave kudada nekupa marabhoritari mhinduro dzakasimbiswa uye dzakasimba uye yakaita basa mukugadzirisa kushomeka kwemapipette matipi mumisika yeCOVID uye isiri-COVID marabhoritari yakaita basa rakakosha muna 2020. zvakakonzera kuderedzwa kunopfuura 90% kwepipette tip zvinodiwa uye kuderedzwa kukuru kwemutengo uye tsvina yepurasitiki.Tiri pano kutsigira indasitiri uye kuita kuti maLabs ose azive kuti Grenova ine mhinduro yakagadzikana kune pipette tip supply chain.Secerely, Ali Safavi Mutungamiri uye CEO Grenova, Inc.
Wow. Chemist yese yelab pamwe inoagadzira kubva mumachubhu egirazi (bata chubhu kumagumo ega ega, pisa pakati pebunson burner, dhonza zvishoma nezvishoma…buda muhuni… tora mapipette maviri nekukurumidza). kuratidza zera rangu...
Nguva yekutumira: May-24-2022