Cov lus qhia txo qis qis me me, pheej yig, thiab tseem ceeb rau kev tshawb fawb.Nws muaj zog tshawb fawb txog cov tshuaj tshiab, Covid-19 kev kuaj mob thiab txhua yam kev kuaj ntshav.
Tab sis tam sim no, muaj kev cuam tshuam tsis tu ncua hauv cov kav dej pipette vim yog hluav taws xob hluav taws xob, hluav taws kub thiab kev xav tau ntawm kev sib kis tau tsim muaj kev cuam tshuam thoob ntiaj teb uas cuam tshuam ze li txhua lub ces kaum ntawm lub zej zog kev tshawb fawb.
Ib qho kev tsis txaus ntawm cov lus qhia pipette tau ua rau muaj kev cuam tshuam rau kev pabcuam thoob tebchaws los tshuaj xyuas cov menyuam yug tshiab rau cov kabmob uas tuaj yeem ua rau tuag taus, xws li tsis muaj peev xwm zom cov suab thaj hauv cov kua mis.Nws hem cov tsev kawm ntawv qib cell genetics thwmsim.Nws tseem yuam cov tuam txhab biotech ua haujlwm los tsim cov tshuaj tshiab los xav txog. muab qhov tseem ceeb rau qee qhov kev sim dua lwm tus.
Tam sim no, tsis muaj lub cim qhia tias qhov kev tsis txaus yuav xaus txhua lub sijhawm sai sai - yog tias muaj xwm txheej hnyav dua, cov kws tshawb fawb yuav tau pib ncua kev sim lossis txawm tso tseg qee qhov haujlwm.
Gabrielle Bostwick, tus thawj coj hauv chaw soj nstuam ntawm Octant Bio, California-based synthetic biology startup hais tias "Lub tswv yim ntawm kev muaj peev xwm ua kev tshawb fawb yam tsis muaj lawv yog ludicrous."
Ntawm tag nrho cov kws tshawb fawb chim siab txog qhov tsis txaus, cov kws tshawb fawb tau ua haujlwm nrog kev tshuaj xyuas cov menyuam yaus yog cov koom haum tshaj plaws thiab hais tawm.
Cov chaw saib xyuas kev noj qab haus huv hauv zej zog tshuaj xyuas cov menyuam mos rau ntau ntau yam kab mob hauv cov sij hawm xa tuaj.Qee yam, xws li phenylketonuria thiab MCAD tsis txaus, xav kom cov kws kho mob hloov kho tam sim rau txoj kev saib xyuas lawv cov me nyuam.Raws li kev tshawb fawb xyoo 2013, txawm tias qeeb hauv kev tshuaj ntsuam. txheej txheem ua rau qee tus menyuam mos tuag.
Kev tshuaj xyuas txhua tus menyuam yuav tsum muaj txog 30 txog 40 cov lus qhia kom ua tiav ntau qhov kev kuaj mob, thiab ntau txhiab tus menyuam yug hauv Tebchaws Meskas txhua hnub.
Rov qab rau Lub Ob Hlis, cov chaw sim tau qhia meej tias lawv tsis muaj cov khoom siv uas lawv xav tau.Laboratories hauv 14 lub xeev muaj tsawg dua ib hlis ntawm cov lus qhia pipette tshuav, raws li Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv.Cov pab pawg tau txhawj xeeb tias nws tau raug thawb tsoomfwv, suav nrog Tsev Dawb, tau ntau lub hlis los saib xyuas qhov tseem ceeb ntawm qhov xav tau cov lus qhia pipette rau txoj haujlwm kuaj menyuam mos.Tam sim no, tsis muaj dab tsi hloov pauv, pab pawg tau hais. Lub Tsev Dawb hais rau STAT tias cov thawj coj tab tom saib ntau yam. txoj hauv kev kom nce cov lus qhia muaj.
Hauv qee qhov kev txiav txim siab, cov yas tsis txaus "yuav luag ua rau kaw qee qhov kev tshuaj ntsuam xyuas menyuam mos," Susan Tanksley, tus thawj tswj hwm ntawm Texas Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv, tau hais rau lub rooj sib tham ntawm Tsoom Fwv Teb Chaws Pabcuam Saib Xyuas Menyuam Yaus Lub Ob Hlis.hais.(Tankkey thiab lub xeev lub chaw saib xyuas kev noj qab haus huv tsis teb rau cov lus thov tawm tswv yim.)
Scott Shone, tus thawj coj ntawm North Carolina Public Health Laboratory, tau hais tias qee lub xeev tau txais ib pawg lus qhia nrog tsuas yog ib hnub dhau los, ua rau lawv tsis muaj kev xaiv tab sis thov kev txhawb nqa los ntawm lwm lub chaw kuaj mob .Sean tau hais tias nws tau hnov ib co neeg saib xyuas kev noj qab haus huv hu " hais tias, 'Kuv tsis tau nyiaj tag kis, koj puas tuaj yeem tau kuv ib hmos?'Vim tus neeg muag khoom hais tias nws tab tom los, tab sis kuv tsis paub qhov ntawd.'
Nws tau hais tias "Ntseeg tias thaum tus neeg muag khoom hais tias, 'Peb hnub ua ntej koj tawm mus, peb yuav muab lwm lub hlis rau koj' - qhov no yog kev ntxhov siab.
Ntau lub chaw kuaj mob tau hloov mus rau lwm txoj hauv kev txiav txim plaub ntug.Qee qhov raug ntxuav thiab rov qab siv dua, ua rau muaj kev pheej hmoo ntawm kev kis kab mob sib kis.Lwm tus tab tom ua cov tshuaj ntsuam xyuas menyuam mos hauv cov khoom siv, uas tuaj yeem ua rau lub sijhawm ua kom tau txais txiaj ntsig.
Txog tam sim no, cov kev daws teeb meem no txaus. "Peb tsis nyob hauv qhov xwm txheej uas tus menyuam yug tshiab raug hem tam sim," Shone ntxiv.
Ntxiv nrog rau cov chaw soj nstuam soj ntsuam cov menyuam mos, cov tuam txhab biotech ua haujlwm ntawm kev kho tshiab thiab cov chaw kuaj mob hauv tsev kawm ua haujlwm ntawm kev tshawb fawb yooj yim tau hnov txog.
Cov kws tshawb fawb ntawm PRA Health Sciences, lub koom haum tshawb fawb txog kev cog lus ua haujlwm ntawm kev sim tshuaj xyuas kab mob siab B thiab ntau tus neeg siv tshuaj Bristol Myers Squibb, hais tias kev xa khoom tsis txaus yog qhov kev hem thawj tsis tu ncua - txawm hais tias lawv tsis tau ncua sijhawm nyeem ntawv.
Jason Neat, tus thawj coj ntawm kev pabcuam bioanalytical ntawm PRA Health hauv Kansas tau hais tias "Qee lub sijhawm, nws hloov mus ua kab lus qhia ntawm lub txee tom qab, thiab peb zoo li 'oh my gosh,"
Kathleen McGinness, tus thawj coj ntawm RNA biology ntawm Arrakis Therapeutics, lub tuam txhab ua haujlwm ntawm kev kho mob qog noj ntshav, kab mob hauv lub paj hlwb thiab cov kab mob tsis tshua muaj, tsim ib qho kev mob siab rau Slack channel los pab nws cov npoj yaig qhia cov ntaub ntawv.Kev daws teeb meem los tiv thaiv cov lus qhia pipette.
"Peb paub tias nws tsis hnyav," nws hais ntawm #tipsfortips channel.
Feem ntau ntawm cov tuam txhab biotech STAT tau hais rau hais tias lawv tau ua cov kauj ruam los tiv thaiv cov pipettes tsawg thiab txog tam sim no tseem tsis tau tso tseg.
Piv txwv li, cov kws tshawb fawb ntawm Octant muaj kev xaiv zoo heev thaum nws los txog rau kev siv cov lus qhia lim pipette.Cov lus qhia - uas tau nyuaj heev los ntawm cov hnub no - muab cov txheej txheem tiv thaiv ntxiv rau cov qauv los ntawm cov kab mob sab nraud, tab sis tsis tuaj yeem ua kom tsis muaj menyuam thiab rov siv dua. .Yog li ntawd, lawv tshwj xeeb rau lawv rau kev ua ub no uas tej zaum yuav muaj kev cuam tshuam tshwj xeeb.
Danielle de Jong, tus thawj coj hauv chav kuaj mob ntawm Whitney Laboratory ntawm University of Florida hais tias, "Yog tias koj tsis xyuam xim rau qhov koj siv, koj tuaj yeem khiav tawm yooj yim," hais tias Danielle de Jong, tus thawj coj hauv chav kuaj mob ntawm Whitney Laboratory ntawm University of Florida, qhov chaw nws yog ib feem ntawm lub chaw kuaj mob uas kawm txog cov qia. hlwb ua haujlwm hauv cov tsiaj me me uas cuam tshuam nrog jellyfish.Kev ua haujlwm, cov tsiaj no tuaj yeem tsim ib feem ntawm lawv tus kheej.
Cov kws tshawb fawb ntawm Whitney Lab qee zaum them nyiaj tawm ntawm lawv cov neeg nyob ze thaum cov xaj xaj tsis tuaj txog lub sijhawm.de Jong txawm pom nws tus kheej tau khawb lub rhawv ntawm lwm qhov chaw sim rau cov lus qhia tsis siv pipette yog tias nws lub chaw kuaj mob xav tau qiv qee qhov.
Nws tau hais tias "Kuv tau nyob hauv chav kuaj tau 21 xyoos," nws hais tias.Puas tau.”
Xyoo tas los qhov kev tawg tam sim ntawm Covid-19 qhov kev sim - txhua qhov tso siab rau cov lus qhia pipette - yeej ua tau lub luag haujlwm.Tab sis qhov cuam tshuam ntawm kev puas tsuaj ntuj tsim thiab lwm yam xwm txheej txawv txawv nyob rau hauv cov khoom siv tau spilled mus rau lub rooj ntev zaum.
Kev puas tsuaj loj thoob plaws xeev hauv Texas tau tua ntau dua 100 tus neeg thiab cuam tshuam qhov txuas tseem ceeb hauv cov kav dej pipette complex.Qhov kev tawm tsam tau yuam Exxon thiab lwm lub tuam txhab kaw ib ntus hauv lub xeev - qee qhov ua rau polypropylene resin, cov khoom siv raw rau cov lus qhia pipette.
Exxon's Houston-thaj chaw cog yog lub tuam txhab thib ob-loj tshaj plaws polypropylene tsim nyob rau hauv 2020, raws li daim ntawv tshaj tawm Lub Peb Hlis;Tsuas yog nws cov nroj tsuag Singapore tsim ntau dua.Ob ntawm ExxonMobil peb qhov loj tshaj plaws polyethylene cov nroj tsuag tseem nyob hauv Texas.(Lub Plaub Hlis 2020, ExxonMobil txawm nce polypropylene ntau lawm ntawm ob lub US nroj tsuag.)
"Tom qab cua daj cua dub thaum Lub Ob Hlis xyoo no, nws kwv yees tias ntau dua 85% ntawm lub peev xwm polypropylene hauv Tebchaws Meskas tau cuam tshuam los ntawm ntau yam teeb meem xws li cov kav xa hluav taws xob, hluav taws xob, thiab hluav taws xob tawm ntawm cov chaw tsim khoom.Ib qho tseem ceeb raw khoom uas yuav tsum tau rov pib dua, ”said lwm tus neeg tsim khoom ntawm polypropylene.Tus cev lus rau Houston-based roj thiab roj tuam txhab Total tau hais.
Tab sis cov saw hlau tau nyob rau hauv siab txij li lub caij ntuj sov dhau los - zoo ua ntej qhov sib sib zog nqus khov hauv Lub Ob Hlis. Cov khoom siv qis dua li ib txwm tsis yog ib qho uas txwv cov saw hlau - tsis yog cov lus qhia pipette tsuas yog cov khoom siv yas hauv cov khoom siv luv luv. .
Kev tsim hluav taws xob tsim hluav taws xob kuj cuam tshuam cov khoom siv ntawm 80 feem pua ntawm lub teb chaws cov thawv siv cov lus qhia pipette thiab lwm yam ntse, raws li cov ntaub ntawv tshaj tawm hauv University of Pittsburgh lub vev xaib.
Thaum Lub Xya Hli, Asmeskas Kev Cai Lij Choj thiab Kev Tiv Thaiv Ciam Teb tau pib thaiv cov khoom lag luam los ntawm cov tuam txhab hnab looj tes loj uas xav tias yuav raug yuam ua haujlwm.(CBP tso tawm nws qhov kev tshawb pom lub hli dhau los.)
"Qhov peb pom tiag tiag yog qhov kev lag luam ntsig txog yas - polypropylene tshwj xeeb - yog tawm ntawm cov khoom lag luam lossis xav tau siab," said PRA Health Sciences 'Neat.
Tiffany Harmon, tus thawj coj ntawm PRA Health Sciences ' bioanalytical laboratory hauv Kansas hais tias qhov kev xav tau siab heev uas tus nqi rau qee yam khoom siv tsis txaus tau nce.
Lub tuam txhab tam sim no them 300% ntau dua rau cov hnab looj tes los ntawm nws cov neeg muab khoom ib txwm muaj.PRA qhov kev txiav txim siab pipette tam sim no muaj rau tus nqi ntxiv.A cov chaw tsim khoom ntawm cov lus qhia pipette, uas lub hli dhau los tshaj tawm tus nqi tshiab ntawm 4.75 feem pua, hais rau nws cov neeg siv khoom qhov kev txav yog tsim nyog. vim tias tus nqi ntawm cov khoom siv yas tau ze li ob npaug.
Ntxiv rau qhov tsis paub meej rau cov kws tshawb fawb hauv chav kuaj yog tus txheej txheem uas cov neeg faib khoom txiav txim siab seb qhov kev txiav txim yuav raug sau ua ntej - ob peb tus kws tshawb fawb hais tias lawv nkag siab tias qhov no ua haujlwm li cas.
Shone hais tias, "Lub zej zog lab tau thov txij thaum pib los pab peb nkag siab tias cov kev txiav txim siab no tau ua li cas," said Shone, uas hu rau cov neeg muag khoom siv los txiav txim siab faib "black-box magic."
STAT hu rau ntau tshaj li kaum lub tuam txhab uas tsim lossis muag cov lus qhia pipette, suav nrog Corning, Eppendorf, Fisher Scientific, VWR thiab Rainin.Tsuas muaj ob lo lus teb.
Corning tsis kam tawm tswv yim, hais txog kev pom zoo nrog cov neeg siv khoom. Lub caij no, MilliporeSigma tau hais tias nws faib cov pipettes ua ntej, ua ntej ua ntej.
"Kev thov rau Covid-19-txog cov khoom lag luam, suav nrog MilliporeSigma, tsis tau muaj nyob hauv kev lag luam kev tshawb fawb txog lub neej txij li thaum muaj kev sib kis," tus kws tshaj lij rau lub tuam txhab xa khoom siv tshawb fawb tseem ceeb tau hais rau STAT hauv tsab ntawv xa email. "Peb tab tom ua haujlwm 24. "
Txawm hais tias muaj kev sim ua kom cov khoom sib txuas ntxiv, nws tsis paub meej tias qhov tsis txaus yuav kav ntev npaum li cas.
Corning tau txais $ 15 lab los ntawm US Department of Defense los tsim ib qho ntxiv 684 lab pipette cov lus qhia txhua xyoo ntawm nws qhov chaw nyob hauv Durham, North Carolina.Tecan tseem siv txoj cai CARES Txoj Cai $ 32 lab los tsim cov chaw tsim khoom tshiab.
Tab sis qhov ntawd yuav tsis daws qhov teeb meem yog tias cov khoom yas tseem qis dua li qhov xav tau. Txawm li cas los xij, tsis muaj ib qho ntawm cov haujlwm no yuav tuaj yeem tsim cov lus qhia pipette thaum lub caij nplooj zeeg 2021.
Txog thaum ntawd, cov thawj coj hauv chav kuaj thiab cov kws tshawb fawb tab tom npaj rau qhov tsis txaus ntawm pipettes thiab lwm yam.
"Peb tau pib kis tus kabmob kis no yam tsis muaj swabs thiab tsis muaj xov xwm.Tom qab ntawd peb muaj qhov tsis txaus ntawm cov tshuaj reagents.Tom qab ntawd peb muaj qhov tsis txaus ntawm cov yas.Tom qab ntawd peb muaj qhov tsis txaus ntawm cov tshuaj reagents, "North Carolina's Shone tau hais tias "Nws zoo li Groundhog Hnub."
Hloov tshiab: Tom qab zaj dab neeg no tau tshaj tawm, MilliporeSigma tau piav qhia tias nws siv cov txheej txheem ua ntej, thawj zaug ua haujlwm los faib cov lus qhia pipette, tsis yog cov txheej txheem plaub txheej uas nws tau piav qhia hauv keeb kwm.Cov dab neeg tam sim no qhia txog kev hloov tshiab ntawm lub tuam txhab.
Kate sau thiab txheeb xyuas cov ntaub ntawv, cov ntaub ntawv thiab lwm yam ntaub ntawv rau biotech, kev noj qab haus huv tech, kev tshawb fawb thiab kev nom kev tswv.
Kate, qhov no yog ib tsab xov xwm zoo los qhia rau txhua tus neeg paub txog cov kev sib tw tseem ceeb hauv kev lag luam.Kuv xav qhia rau koj tias Grenova (www.grenovasolutions.com) tau txaus siab los muab cov chaw soj nstuam nrog cov pov thawj thiab cov kev daws teeb meem ruaj khov thiab tau ua lub luag haujlwm hauv kev hais txog qhov tsis txaus ntawm cov lus qhia pipette hauv COVID thiab tsis yog-COVID kev lag luam kev lag luam tau ua lub luag haujlwm tseem ceeb hauv xyoo 2020.Hauv cov chaw soj nstuam siv Grenova Tip Washers, txhua lub taub pipette tau ntxuav thiab rov siv dua ntau dua 15 zaug ntawm qhov nruab nrab.Qhov no muaj ua rau muaj ntau tshaj li 90% txo cov kev xav tau ntawm pipette tip thiab txo cov nqi thiab cov yas pov tseg.Peb nyob ntawm no los txhawb kev lag luam thiab qhia rau txhua qhov chaw sim paub tias Grenova muaj cov kev daws teeb meem zoo dua rau cov pipette tip supply chain.Ua tsaug, Ali Safavi Thawj Tswj Hwm thiab CEO Grenova, Inc.
Wow.Txhua tus kws kuaj mob kuaj mob tej zaum yuav ua rau lawv tawm ntawm cov raj iav (tuav lub raj ntawm txhua qhov kawg, ua kom sov nruab nrab ntawm lub qhov cub tawg, rub maj mam… tawm ntawm lub qhov cub… tau 2 pipettes sai).Kuv tawm ntawm qhov kov thiab qhia kuv lub hnub nyoog…
Post lub sij hawm: May-24-2022