Ingcebiso ethobekileyo yepipette incinci, ayibizi, kwaye ibalulekile kwisayensi. Inika amandla uphando kumayeza amatsha, uxilongo lwe-Covid-19 kunye novavanyo ngalunye lwegazi.
Kodwa ngoku, uthotho lokuphazamiseka okungalindelekanga kwikhonkco lokubonelela ngepipette ngenxa yokucima kombane, imililo kunye neemfuno ezinxulumene nobhubhane zidale ukunqongophala kwehlabathi okusongela phantse zonke iimbombo zoluntu lwezenzululwazi.
Ukunqongophala kweengcebiso ze-pipette kubeke emngciphekweni inkqubo yelizwe lonke yokuhlola iintsana ezisanda kuzalwa kwizifo ezinokuthi zibulale, ezifana nokungakwazi ukwetyisa iswekile kubisi lwebele.Iyoyike i-experimenti ye-stem cell genetics eyunivesithi.Ikwanyanzelisa iinkampani ze-biotech ezisebenza ekuphuhliseni amachiza amatsha ukuba aqwalasele ukubeka phambili imifuniselo ethile kunezinye.
Okwangoku, akukho mqondiso wokuba ukunqongophala kuya kuphela nangaliphi na ixesha kwakamsinya- ukuba izinto ziya ziba mandundu, izazinzulu kusenokufuneka ziqale ukulibazisa iimvavanyo okanye ziwuyeke umsebenzi wazo.
“Umbono wokukwazi ukwenza isayensi ngaphandle kwabo uyahlekisa,” utshilo uGabrielle Bostwick, umphathi zelabhoratri e-Octant Bio, uqalo lwebhayoloji esekwe eCalifornia.
Kuzo zonke izazinzulu ezicaphukisayo malunga nokunqongophala, abaphandi abanikwe umsebenzi wokuhlola iintsana ngabona bahlelekile kwaye bathetha ngokuphandle.
Iilebhu zezempilo zoluntu zihlola iintsana ezininzi zokuphazamiseka kwemfuza kwiiyure nje zokubeleka.Ezinye, ezifana nephenylketonuria kunye nokusilela kwe-MCAD, zifuna ukuba oogqirha benze utshintsho olukhawulezileyo kwindlela abakhathalela ngayo iintsana zabo.Ngokophando luka-2013, nokulibaziseka ekuhlolweni. inkqubo ikhokelele ekuswelekeni kweentsana ezithile.
Ukuhlolwa komntwana ngamnye kufuna amacebiso amalunga nama-30 ukuya kwangama-40 ukugqiba intaphane yovavanyo lokuxilonga, kwaye amawakawaka abantwana azalelwa eUnited States yonke imihla.
Emuva ngoFebruwari, iilebhu zakwenza kwacaca ukuba zazingenazo izinto ezifunekayo.IiLabhoratri kwii-14 zamazwe zineengcebiso ezingaphantsi kweenyanga ze-pipette ezisele, ngokutsho kwe-Association for Public Health Laboratories.Iqela lixhalabele kakhulu ukuba uye wacinezela urhulumente wesigqeba, kuquka i-White House, iinyanga ukuba zibeke phambili imfuno yeengcebiso ze-pipette zeprogram yokuhlola usana olusanda kuzalwa.Kuze kube ngoku, akukho nto itshintshileyo, iqela lathi.I-White House yatshela i-STAT ukuba ulawulo lujonge ezininzi iindlela zokunyusa ukufumaneka kweengcebiso.
Kwamanye amagunya, ukunqongophala kweplastiki "kuphantse kwakhokelela ekuvalweni kweenkqubo zokuhlola usana olusandul' ukuzalwa," uSusan Tanksley, umphathi wecandelo leCandelo leeNkonzo zeLebhu yeSebe lezeMpilo laseTexas, uxelele intlanganiso yeKomiti yeeNgcebiso zeFederal kuHlolo olusanda kuzalwa ngoFebruwari.watsho.(I-Tankskey kunye nesebe lezempilo likarhulumente alizange liphendule kwizicelo zokuphawula.)
UScott Shone, umlawuli weNorth Carolina Public Health Laboratory, uthe amanye amazwe afumene ibhetshi yeengcebiso kushiyeke usuku nje olunye, ebashiya bengenandlela mbini ngaphandle kokucela inkxaso kwezinye iilebhu. ukuthi, 'Ndiphelelwa yimali ngomso, ungandithengela into ngobusuku nje?'Kuba umthengisi uthe uyeza, kodwa ndandingayazi loo nto.’”
“Kholelwa ukuba xa lo mthengisi esithi, 'Kwiintsuku ezintathu phambi kokuba uphelelwe, siza kukunika enye inyanga' – yinkxalabo leyo,” utshilo.
Iilebhu ezininzi ziguqukele kwiindlela ezizezinye ze-jury manipulation.Ezinye ziyacocwa kwaye ziphinde zisetyenziswe, zinyusa umngcipheko wokunqanda ukungcoliseka.Abanye benza uhlolo olusanda kuzalwa kwiibhetshi, ezinokunyusa ixesha elithathayo ukunika iziphumo.
Ukuza kuthi ga ngoku, ezi zicombululo zanele.
Ukongeza kwiilabhoratri zokuhlola iintsana ezisanda kuzalwa, iinkampani zebhayoloji ezisebenza kunyango olutsha kunye neelebhu zaseyunivesithi ezisebenza kuphando olusisiseko ziziva zixinene.
Iingcali zenzululwazi kwi-PRA Health Sciences, umbutho wophando lwekhontrakthi osebenza kwiimvavanyo zeklinikhi ze-hepatitis B kunye nabaviwa abaninzi beziyobisi ze-Bristol Myers Squibb, bathi ukuthotywa konikezelo kusisongelo esiqhubekayo - nangona bengakhange balibazise ngokusemthethweni naluphi na ufundo.
"Ngamanye amaxesha, ijika ibe ngumqolo weengcebiso kwi-shelf yangasemva, kwaye sifana 'oh nkosi yam,'" watsho uJason Neat, umlawuli olawulayo weenkonzo ze-bioanalytical kwi-PRA Health e-Kansas.
UKathleen McGinness, intloko ye-RNA biology kwi-Arrakis Therapeutics, inkampani esebenza kunyango olunokuthi lube nomhlaza, ukuphazamiseka kwe-neurological kunye nezifo ezinqabileyo, yenze i-channel ye-Slack ezinikeleyo yokunceda oogxa bakhe babelane ngolwazi.Isisombululo sokukhusela iingcebiso ze-pipette.
“Siye saqaphela ukuba ayilunganga,” utshilo malunga netshaneli ye-#tipsfortips.” Abantu abaninzi kwiqela bebezijonga ngenkuthalo izisombululo, kodwa besingenayo indawo esembindini yokwabelana nabo.
Uninzi lweenkampani ze-biotech u-STAT wathetha nabo bathi bathatha amanyathelo okukhusela iipipettes ezilinganiselwe kwaye ukuza kuthi ga ngoku aziyekanga ukusebenza.
Ngokomzekelo, izazinzulu zase-Octant zikhetha kakhulu xa kuziwa ekusebenziseni iingcebiso ze-pipette ezihluziweyo. Ezi ngcebiso - eziye zanzima kakhulu ukuza kule mihla - zibonelela ngokhuseleko olongezelelweyo kwiisampulu ezivela kwizinto ezingcolileyo zangaphandle, kodwa azikwazi ukuvalelwa kwaye zisetyenziswe kwakhona. .Ngoko ke, babaqeqeshela imisebenzi enokuba novakalelo olukhethekileyo.
“Ukuba awuyihoyi into oyisebenzisayo, unokuphelelwa lula,” utshilo uDanielle de Jong, umphathi walebhu eWhitney Laboratory kwiDyunivesithi yaseFlorida, apho ayinxalenye yelebhu efunda indlela iiseli zisebenza kwizilwanyana ezincinci zaselwandle ezinxulumene nejellyfish.Ngokusebenza, ezi zilwanyana zinokuphinda zivelise iinxalenye zazo.
Izazinzulu zaseWhitney Lab ngamanye amaxesha zibheyile kubamelwane babo xa imiyalelo yonikezelo ingafiki kwangethuba.de uJong wade wazifumana egqogqa iishelufa zezinye iilebhu ukuze afumane naziphi na iingcebiso ezingasetyenziswayo zepipette xa ilebhu yakhe ifuna ukuboleka.
“Ndineminyaka engama-21 ndiselebhu,” watsho.” Andizange ndibe nengxaki yokuthenga izinto ngolu hlobo.Nanini na.”
Uqhushumbo lonyaka ophelileyo ngequbuliso lovavanyo lwe-Covid-19 - nganye kuzo ixhomekeke kwiingcebiso ze-pipette - ngokuqinisekileyo idlale indima.
Ukumka kombane kwilizwe lonke eTexas kwabulala abantu abangaphezu kwe-100 kwaye kwaphazamisa ikhonkco eliphambili kwikhonkco lonikezelo lwepipette entsonkothileyo. Ukukhutshwa kunyanzelise i-Exxon kunye nezinye iinkampani ukuba zivale okwethutyana iifektri kurhulumente - ezinye zazo zenza i-polypropylene resin, into ekrwada iingcebiso zepipette.
Isityalo se-Exxon's Houston-yendawo yayiyeyesibini kwinkampani enkulu yokuvelisa i-polypropylene ngo-2020, ngokwengxelo kaMatshi;kuphela isityalo sayo sase-Singapore esivelise ngaphezulu.Ezimbini zezityalo ezintathu ze-polyethylene ezinkulu ze-ExxonMobil nazo zikwi-Texas.(Ngo-Epreli ka-2020, i-ExxonMobil iye yanyusa imveliso yepolypropylene kwizityalo ezimbini zase-US.)
“Emva kwezaqhwithi zasebusika ngoFebruwari walo nyaka, kuqikelelwa ukuba ngaphezu kwama-85 ekhulwini omthamo wepolypropylene eUnited States iye yachatshazelwa kakubi ziingxaki ezahlukahlukeneyo ezinjengokugqabhuka kwemibhobho, ukuphela kombane, nokumka kombane kwimizi-mveliso yokuvelisa.Imathiriyeli ekrwada ebalulekileyo efunekayo ukuqalisa kwakhona imveliso,” watsho omnye umvelisi wepolypropylene.Isithethi senkampani ye-oyile kunye negesi e-Houston esekelwe kwiTotal uthe.
Kodwa amatyathanga onikezelo abephantsi koxinzelelo ukusukela kwihlobo elidlulileyo - ngaphambi kokuba kukhenkceke okunzulu ngoFebruwari. Amanqanaba asezantsi kunesiqhelo ezinto ekrwada ayisiyiyo kuphela into enyanzelela amatyathanga onikezelo-kunye neengcebiso ze-pipette kuphela kwezixhobo zelebhu zeplastiki ezinqongopheleyo. .
Umlilo wesityalo sokuvelisa uphazamise ukunikezelwa kweepesenti ze-80 zemigqomo yelizwe yeengcebiso ezisetyenzisiweyo ze-pipette kunye nezinye izinto ezibukhali, ngokutsho koxwebhu olufakwe kwiwebhusayithi yeYunivesithi yasePittsburgh.
NgoJulayi, i-US Customs kunye noKhuseleko lweBorder yaqala ukuvala iimveliso ezivela kumenzi weglavu omkhulu okrokrelwa ngokusebenza ngokunyanzeliswa. (i-CBP ikhuphe iziphumo zayo kwinyanga ephelileyo.)
"Into esiyibonayo ngokwenene kukuba ishishini elinxulumene neeplastiki - i-polypropylene ngokukodwa - iphelile okanye ifunwa kakhulu," kusho i-PRA Health Sciences 'Neat.
Imfuno iphezulu kangangokuba amaxabiso ezinto ezinqabileyo anyukile, utshilo uTiffany Harmon, umlawuli wokuthengwa kwempahla kwi-PRA Health Sciences 'bioanalytical laboratory eKansas.
Inkampani ngoku ihlawula i-300% ngaphezulu kwiiglavu ngokusebenzisa ababoneleli bayo besiqhelo.Ii-oda ze-pipette ze-PRA ngoku ziyafumaneka kwintlawulo eyongezelelweyo.Umvelisi weengcebiso ze-pipette, owathi kwinyanga ephelileyo ubhengeze intlawulo eyongezelelweyo ye-4.75 ekhulwini, uxelele abathengi bayo ukuba ukuhamba kwakuyimfuneko. kuba ixabiso lezinto zeplastiki ekrwada liphantse laphindeka kabini.
Ukongeza kokungaqiniseki kwezazinzulu zaselebhu yinkqubo apho abasasazi bamisela ukuba zeziphi na iiodolo eziza kuzaliswa kuqala—zimbalwa izazinzulu ezithi ziyiqonda ngokupheleleyo indlela oku kusebenza ngayo.
“Uluntu lwaselebhu lucele kwasekuqaleni ukuba lusincede siqonde ukuba zithathwa njani ezi zigqibo,” utshilo uShone, obiza ifomyula esetyenziswa ngabathengisi ukumisela ulwabiwo “lomlingo webhokisi emnyama.”
I-STAT yaqhagamshelana neenkampani ezingaphezu kweshumi elinesibini ezenza okanye ezithengisa iingcebiso ze-pipette, kuquka i-Corning, i-Eppendorf, i-Fisher Scientific, i-VWR kunye ne-Rainin. Kukho iimpendulo ezimbini kuphela.
I-Corning inqabile ukuphawula, ikhankanya izivumelwano zobunikazi kunye nabathengi.Okwangoku, i-MilliporeSigma ithe ikhupha i-pipettes ngokuza kuqala, isiseko sokuqala.
"Imfuno yeemveliso ezinxulumene ne-Covid-19, kubandakanya iMilliporeSigma, ibingakaze ibonwe kwishishini lezesayensi zobomi ukusukela oko kwaqala ubhubhane," isithethi senkampani enkulu yokusasaza izinto zesayensi sixelele i-STAT kwingxelo ye-imeyile. /7 ukuhlangabezana nemfuno ekhulayo yezi mveliso kunye nezo zisetyenziselwa ukufunyaniswa kwenzululwazi. "
Ngaphandle kweenzame zokuqinisa amakhonkco okubonelela, akucaci ukuba ukunqongophala kuya kuhlala ixesha elingakanani.
I-Corning ifumene i-15 yezigidi zeedola kwiSebe lezoKhuselo lase-US ukuvelisa i-684 yezigidi zeengcebiso ze-pipette ngonyaka kwiziko layo e-Durham, North Carolina.I-Tecan ikwasebenzisa i-CARES Act ye-32 yezigidi zeedola ukwakha indawo entsha yokuvelisa.
Kodwa oko akuyi kusombulula ingxaki ukuba ukuveliswa kweplastiki kuhlala kuphantsi kunokuba kulindelwe.Kuyo nayiphi na imeko, akukho nanye yale projekthi iya kukwazi ukuvelisa iingcebiso ze-pipette ngokuwa kwe-2021.
Kude kube lelo xesha, abaphathi beelebhu kunye noosonzululwazi bajonge ukunqongophala ngakumbi kweepipettes kunye nayo nayiphi na enye into.
“Siqale lo bhubhani ngaphandle kwe-swabs nangaphandle kwemithombo yeendaba.Emva koko saba nokunqongophala kwee-reagents.Emva koko sasinqongophele iiplastiki.Emva koko siye sanqongophala kwee-reagents, ”utshilo uShone waseNorth Carolina. "Kufana noSuku lweGroundhog."
Uhlaziyo: Emva kokuba eli bali lipapashwe, i-MilliporeSigma yachaza ukuba isebenzisa inkqubo yokuqala yokuza, eyokuqala ukukhupha iingcebiso ze-pipette, kunokuba inkqubo ye-4-layer echazwe ekuqaleni.Eli bali ngoku libonisa ukuhlaziywa kwinkampani.
UKate uqokelela kwaye ahlalutye amaxwebhu, idatha kunye nolunye ulwazi lwebhayoloji, ubuchwepheshe bezempilo, isayensi kunye namabali ezopolitiko.
Kate, eli linqaku elihle lokugcina wonke umntu enolwazi malunga nale mingeni mikhulu eqhubekayo yokubonelela kwishishini. Ndingathanda ukwabelana nawe ukuba iGrenova (www.grenovasolutions.com) inebhongo ngokubonelela iilabhoratri ngezisombululo eziqinisekisiweyo nezizinzileyo kunye idlale indima ekujonganeni nokunqongophala kweengcebiso zepipette kwi-COVID kunye neemarike zelabhoratri ezingezizo i-COVID zidlale indima ebalulekileyo ngo-2020. kubangele ukuncitshiswa okungaphezulu kwe-90% kwiimfuno zetip ye-pipette kunye nokunciphisa okukhulu kweendleko kunye nenkunkuma yeplastiki.Silapha ukuxhasa ishishini kwaye sazise zonke iilebhu ukuba i-Grenova inesisombululo esizinzileyo kwi-pipette tip supply chain.Ngokuzithoba, U-Ali Safavi uMongameli kunye ne-CEO iGrenova, Inc.
Wow. I-lab chemist nganye mhlawumbi izenza ngeetyhubhu zeglasi (bamba ityhubhu kwisiphelo ngasinye, fudumeza umbindi kwisitshisi se-bunson, tsala kancinci…phuma kwisitshisi…fumana iipipettes ezi-2 ngokukhawuleza). ebonisa iminyaka yam...
Ixesha lokuposa: May-24-2022