Ithiphu ye-pipette ethobekile incane, ishibhile, futhi ibaluleke kakhulu kwisayensi.Inika amandla ucwaningo emithini emisha, ukuhlolwa kwe-Covid-19, nakho konke ukuhlolwa kwegazi okwenzekayo.
Futhi, ngokuvamile, kuningi - usosayensi ojwayelekile webhentshi angase abambe inqwaba nsuku zonke.
Kepha manje, uchungechunge lwamakhefu anesikhathi esingalungile eduze kochungechunge lokuhlinzekwa kwetiphu ye-pipette - olugqugquzelwa ukucisha, imililo, kanye nesidingo esihlobene nobhubhane - sesenze ukushoda komhlaba wonke okusongela cishe wonke amagumbi omhlaba wesayensi.
Ukushoda kwethiphu ye-pipette sekuvele kubeka engcupheni izinhlelo ezweni lonke ezihlola izingane ezisanda kuzalwa izimo ezingase zibulale, njengokungakwazi ukugaya ushukela obisini lwebele.Kusabisa ukuhlola kwamanyuvesi nge-stem cell genetics.Futhi kuphoqa izinkampani ze-biotech ezisebenzela ukuthuthukisa imithi emisha ukuthi zicabange ukubeka kuqala izivivinyo ezithile kunezinye.
Njengamanje, akukho sibonakaliso sokuthi ukushoda kuzophela maduze - futhi uma kuba kubi kakhulu, ososayensi kungenzeka baqale ukuhlehlisa izivivinyo noma bashiye izingxenye zomsebenzi wabo.
Kubo bonke ososayensi abakhathazwa ukushoda, abacwaningi abanomthwalo wemfanelo wokuhlola izinsana yibona abahleleke kakhulu nabakhuluma ngokungagwegwesi.
Amalabhorethri ezempilo yomphakathi ahlola izinsana emahoreni ambalwa ngemva kokubeletha ukuthola inqwaba yezimo zofuzo.Ezinye, njenge-phenylketonuria kanye nokuntuleka kwe-MCAD, zidinga ukuthi odokotela bashintshe ngokushesha ukuthi bayinakekela kanjani ingane.Ngisho nokubambezeleka nje kohlelo lokuhlolwa sekuholele ekufeni kwezingane, ngokophenyo lwango-2013.
Ukuhlolwa kwengane ngayinye kudinga amathiphu angu-30 kuya kwangu-40 ukuze kuqedelwe inqwaba yokuhlolwa kokuxilonga, futhi izinkulungwane zezingane zizalwa usuku ngalunye e-United States.
Kusukela ngoFebhuwari, la ma-labs ayekwenza kucace ukuthi awanazo izinto ezidingekayo.Amalebhu ezifundazweni eziyi-14 anamacebiso angaphansi kwenyanga asele, ngokusho kwe-Association of Public Health Laboratories.Leli qembu belikhathazeke kakhulu kangangokuthi sekuphele izinyanga licindezela uhulumeni wobumbano - okuhlanganisa ne-White House - ukuthi abeke phambili izidingo zethiphu ye-pipette yezinhlelo zokuhlola izingane ezisanda kuzalwa.Kuze kube manje, le nhlangano ithi, akukho okushintshile;i-White House itshele i-STAT ukuthi uhulumeni usebenza ngezindlela eziningi zokwandisa ukutholakala kwamathiphu.
Kwezinye izindawo, ukushoda kwamapulasitiki “kucishe kwabangela ukuthi izingxenye zezinhlelo zokuhlolwa kwezingane ezisanda kuzalwa zivalwe,” kusho uSusan Tanksley, umphathi wegatsha ophikweni lwezinsizakalo zaselabhorethri yomnyango wezempilo eTexas, ngesikhathi somhlangano wangoFebhuwari wekomiti labeluleki likahulumeni mayelana nokuhlolwa kwezinsana. .(I-Tankskey kanye nomnyango wezempilo wezwe abazange baphendule esicelweni sokuphawula.)
Ezinye izifundazwe zithola inqwaba yamathiphu sekusele usuku olulodwa kuphela, okuzishiya zincane ukukhetha ngaphandle kokucela amanye amalebhu ukuze athole isipele, ngokusho kukaScott Shone, umqondisi welabhorethri yezempilo yomphakathi eNorth Carolina.U-Shone uthe uzwile ngezikhulu zezempilo zomphakathi ezifonayo “zithi, 'Ngizophuma kusasa, ungangitshela okuthile?'Ngoba umthengisi uthi iyeza, kodwa angazi.'
"Ukwethemba lapho lowo mthengisi ethi, 'Izinsuku ezintathu ngaphambi kokuthi uphelelwe, sizokutholela enye inyanga' - ukukhathazeka," esho.
Amalebhu amaningi aphendukele kwezinye izindlela eziboshwe ngamajaji.Abanye bawasha amathiphu bese bewasebenzisa kabusha, okwandisa ingozi engaba khona yokutheleleka ngegciwane.Abanye basebenzisa ukuhlolwa kwezingane ezisanda kuzalwa ngamaqoqo, okungase kwandise isikhathi esisithathayo ukuletha imiphumela.
Kuze kube manje, lezi zixazululo zanele.“Asikho esimweni lapho kusengozini khona izingane ezisanda kuzalwa,” kwengeza u-Shone.
Ngaphandle kwamalebhu ahlola izingane ezisanda kuzalwa, izinkampani ze-biotech ezisebenza ekwelapheni okusha kanye nezindawo zokucwaninga zasenyuvesi ezenza ucwaningo oluyisisekelo nazo ziyakuzwa ukuminya.
Ososayensi kwa-PRA Health Sciences, inhlangano yocwaningo lwenkontileka esebenza ekuhlolweni kwemitholampilo yesifo sokusha kwesibindi kohlobo B kanye nedlanzana labantu abadinga imishanguzo iBristol Myers Squibb, bathi ukuphela kwempahla kuwusongo oluqhubekayo - nakuba bengakaphoqeki ukuthi babambezele ngokusemthethweni noma yikuphi ukufundwa.
"Ngezinye izikhathi, ifika phansi endaweni eyodwa yamathiphu ehlezi eshalofini elingemuva, futhi sifana 'Oh Nkosi yami,'" kusho uJason Neat, umqondisi omkhulu wezinsizakalo ze-bioanalytical lab ye-PRA Health eKansas.
Ukushoda sekuye kwethusa ngokwanele e-Arrakis Therapeutics, inkampani yakwa-Waltham, Mass. esebenza ekwelapheni okungenzeka komdlavuza, izimo zemizwa, nezifo ezingavamile, ukuthi inhloko yayo ye-RNA biology, u-Kathleen McGinness, idale isiteshi esizinikele se-Slack ukusiza ozakwabo ukwabelana. izixazululo zokulondoloza amathiphu e-pipette.
"Sibonile ukuthi lokhu bekungekubi," esho ngesiteshi, #tipsfortips.“Iqembu eliningi belizimisele kakhulu ngezisombululo, kodwa besingenayo indawo emaphakathi yokwabelana ngalokho.”
Iningi lezinkampani ze-biotech okwaxoxwa nazo yi-STAT zathi zithatha izinyathelo zokonga amapayipi alinganiselwe futhi, kuze kube manje, akumele zimise umsebenzi.
Ososayensi be-Octant, isibonelo, bakhetha kakhulu ukusebenzisa amathiphu ahlungiwe we-pipette.Lawa mathiphu - okunzima kakhulu ukuwathola kamuva nje - anikeza amasampuli isendlalelo esengeziwe sokuvikela ekungcoleni kwangaphandle, kodwa awakwazi ukuhlanzwa futhi asetshenziswe kabusha.Ngakho-ke bazinikezela emisebenzini engase ibe bucayi kakhulu.
“Uma unganakile ukuthi yini ephelayo, ungase uphelelwe izinto kalula,” kusho uDanielle de Jong, umphathi ngelebhu eWhitney Laboratory yaseNyuvesi yaseFlorida;ilebhu asebenza kuyo ocwaningweni ukuthi ama-stem cells asebenza kanjani ezilwaneni ezincane zasolwandle ezihlobene ne-jellyfish ezingakhiqiza kabusha izingxenye zazo.
Ososayensi e-Whitney Laboratory, ngezinye izikhathi, baye bahlenga omakhelwane babo lapho ama-oda wokuphakela engafikanga ngesikhathi;U-de Jong useze wazibamba ebuka amashalofu amanye amalebhu ukuthola noma yimaphi amathiphu e-pipette angasetshenziswa, uma nje ilebhu yakhe idinga ukuboleka.
“Ngineminyaka engu-21 ngisebenza elebhu,” kusho yena.“Angikaze ngihlangabezane nezinkinga ezifana nalezi.Njalo.”
Ayikho incazelo eyodwa yokushoda.
Ukuqhuma okungazelelwe kokuhlolwa kwe-Covid-19 ngonyaka owedlule - ngakunye okuncike kumathiphu we-pipette - kudlale indima.Kepha imiphumela yezinhlekelele zemvelo nezinye izingozi ezingalindelekile ziqhubekela phambili nochungechunge lokuhlinzeka nazo ziye zehlela emabhentshini aselabhorethri.
Ukucinywa kukagesi ezweni lonke eTexas, okubulale abantu abangaphezu kwe-100, kuphinde kwephula isixhumanisi esibucayi kuchungechunge lokuhlinzekwa kwe-pipette.Lokho kucisha kukagesi kwaphoqa i-ExxonMobil nezinye izinkampani ukuthi zivalwe okwesikhashana izitshalo esifundazweni - ezinye zazo ezakha inhlaka ye-polypropylene, into eluhlaza yamathiphu e-pipette.
Ngokwesethulo sikaMashi, imboni yase-ExxonMobil yaseHouston ibingumkhiqizi wesibili ngobukhulu wenkampani we-polypropylene ngo-2020;isitshalo sayo saseSingapore kuphela esenze okwengeziwe.Izitshalo ezimbili ze-ExxonMobil ezintathu ezinkulu ze-polyethylene nazo zazitholakala eTexas.(Ngo-Ephreli 2020, i-ExxonMobil yaze yanyusa ukukhiqizwa kwe-polypropylene ezitshalweni ezimbili ezizinze e-US.)
“Ngemuva kwesiphepho sasebusika ngoFebhuwari walo nyaka, kulinganiselwa ukuthi ngaphezu kuka-85% amandla okukhiqiza i-polypropylene e-US athinteke kabi ngenxa yezinkinga ezihlukahlukene njengamapayipi aphukile ezimbonini ezikhiqizayo kanye nokulahlekelwa ugesi nogesi. izinto zokusetshenziswa ezibalulekile ezidingekayo ukuze kuqalwe kabusha ukukhiqiza,” kusho umkhulumeli weTotal, enye inkampani kawoyela negesi eseHouston ekhiqiza i-polypropylene.
Kepha amaketanga okuhlinzeka agcizelelwe kusukela ehlobo eledlule - ngaphambi nje kokuba kube yiqhwa okujulile ngoFebhuwari.Amanani aphansi kunokuvamile ezinto zokusetshenziswa akusona ukuphela kwento enyakazisa amaketanga - futhi amathiphu e-pipette akuwona kuphela ucezu lwegiya elebhu elisekelwe epulasitiki elikade lishoda.
Umlilo wemboni ekhiqizayo uphinde wasusa u-80% wamakhonteyina asetshenziswa ezweni ukuze athole amathiphu e-pipette asetshenzisiwe nezinye izinto ezicijile, ngokombhalo ofakwe kusizindalwazi seNyuvesi yasePittsburgh.
Futhi ngoJulayi, i-US Customs and Border Protection yaqala ukuvimba imikhiqizo evela kumkhiqizi omkhulu wamagilavu osolwa ngemikhuba yokusebenza ephoqelelwe.(I-CBP ikhiphe okutholwe ngophenyo lwayo ngenyanga edlule.)
"Esikubonayo empeleni noma yini engxenyeni yebhizinisi ehlobene namapulasitiki - i-polypropylene, ikakhulukazi - i-backorder, noma idingeka kakhulu," kusho i-PRA Health Sciences' Neat.
Isidingo siphezulu kangangokuthi intengo yezinto eziyivelakancane ikhuphukile, ngokusho kukaTiffany Harmon, umqondisi wokuthengwa kwempahla e-PRA Health Sciences 'bioanalytics lab eKansas.
Inkampani manje isikhokha u-300% ngaphezulu wamagilavu ngomnikezeli wayo ojwayelekile.Futhi ama-oda amathiphu we-pipette we-PRA manje anemali eyengeziwe efakiwe.Omunye umkhiqizi we-pipetti tip, omemezele inkokhiso entsha engu-4.75% ngenyanga edlule, utshele amakhasimende ayo ukuthi lesi sinyathelo besibalulekile ngoba intengo yezinto zepulasitiki eluhlaza icishe yaphindeka kabili.
Okwenezela ekungabazeni kososayensi baselabhorethri inqubo yabasabalalisi yokunquma ukuthi imaphi ama-oda azogcwaliswa kuqala - ukusebenza ososayensi abambalwa abathi bakuqonda ngokugcwele.
"Umphakathi waselabhu ubulokhu ucela kwasekuqaleni ukuthi usisize siqonde ukuthi lezi zinqumo zenziwa kanjani," kusho uShone, obize amafomula abathengisi okunquma izabelo "njengomlingo webhokisi elimnyama."
I-STAT ithinte izinkampani ezingaphezu kweshumi nambili ezikhiqiza noma ezithengisa amathiphu e-pipette, okuhlanganisa i-Corning, i-Eppendorf, i-Fisher Scientific, i-VWR, ne-Rainin.Kwasabela ababili nje.
UCorning wenqabile ukuphawula, ecaphuna izivumelwano zobunikazi namakhasimende akhe.I-MilliporeSigma, ngakolunye uhlangothi, ithe yabela ama-pipettes ngokufika kokuqala, isisekelo sokuqala.
"Selokhu kwaqubuka lolu bhubhane, yonke imboni yesayensi yezempilo ihlangabezane nesidingo esingakaze sibonwe semikhiqizo ehlobene ne-Covid-19, okubandakanya iMilliporeSigma," umkhulumeli wenkampani enkulu esabalalisa izinto zesayensi utshele i-STAT esitatimendeni esithunyelwe nge-imeyili."Sisebenza 24/7 ukuhlangabezana nalesi sidingo esandayo sale mikhiqizo kanye naleyo esetshenziswa ekutholweni kwesayensi."
Naphezu kwemizamo yokuqinisa i-supply chain, akucaci ukuthi ukushoda kuzohlala isikhathi esingakanani.
I-Corning ithole amaRandi ayizigidi eziyi-15 eMnyangweni Wezokuvikela ukwenza amanye amathiphu angama-pipette ayizigidi ezingama-684 ngonyaka esikhungweni sayo eDurham, NC Tecan, futhi, yakha izindawo zokukhiqiza ezintsha ngama- $ 32 wezigidi ezivela ku-CARES Act.
Kodwa lokho ngeke kulungise inkinga uma ukukhiqizwa kwamapulasitiki kuhlala kuphansi kunalokho obekulindelwe.Futhi akukho kulawo maphrojekthi azokwazi ukukhiqiza amathiphu we-pipette ngaphambi kokuwa kuka-2021, noma kunjalo.
Kuze kube yileso sikhathi, abaphathi baselabhorethri nososayensi babheke ukushoda okwengeziwe kwama-pipettes nanoma yini enye.
“Siqale lolu bhubhane sishoda ngama-swabs nabezindaba.Futhi-ke saba nokushoda kwama-reagents.Bese kuba nokushoda kwamapulasitiki.Sabe sesiba nokushoda kwama-reagents futhi, ”kusho uShone waseNorth Carolina."Kufana noSuku Lwezingulube."
Isikhathi sokuthumela: Feb-12-2022